Inventors:
Martin Murphy - St. Helena CA, US
John Schullek - Santa Clara CA, US
John Ward - Redwood City CA, US
Gary Look - Santa Clara CA, US
Brian Siesel - San Francisco CA, US
Assignee:
Propharmacon, Inc. - San Jose CA
International Classification:
A61K 31/55
A61K 31/53
A61K 31/497
A61K 31/506
A61K 31/4439
C07D 403/02
US Classification:
514210200, 514217040, 514217050, 514217060, 514242000, 514255050, 514256000, 514340000, 544183000, 544331000, 544405000, 546268400, 540598000, 540601000
Abstract:
The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.
