Brett E Bouma

6341036, Jan 22, 2002

Aug 24, 2000

09/622971

Guillermo J. Tearney - Cambridge MA
Brett E. Bouma - Quincy MA
Robert H. Webb - Lincoln MA

The General Hospital Corporation - Boston MA

G02B 2100

359368, 359209

A scanning confocal microscopy system, especially useful for endoscopy with a flexible probe which is connected to the end of an optical fiber( ). The probe has a grating( ) and a lens( ) which delivers a beam of multi-spectral light having spectral components which extend in one dimension across a region of an object and which is moved to scan in another dimension. The reflected confocal spectrum is measured to provide an image of the region.

6421164, Jul 16, 2002

Jun 13, 2001

09/880120

Guillermo Tearney - Cambridge MA
Brett E. Bouma - Boston MA
James G. Fujimoto - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

G02F 111

359287, 359285, 359331, 356450, 356484, 25022712, 25022727

An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the mirror tilt produce a change in optical group and phase delay. This apparatus permits the optical group and phase delay to be scanned by scanning the angle of the mirror. In other embodiments, this device permits optical delay scanning without the use of moving parts.

6485413, Nov 26, 2002

Mar 6, 1998

09/036283

Stephen A. Boppart - Boston MA
Gary J. Tearney - Cambridge MA
Brett E. Bouma - Boston MA
Mark E. Brezinski - Malden MA
James G. Fujimoto - Cambridge MA
Eric A. Swanson - Acton MA

The General Hospital Corporation - Boston MA

A61B 106

600160, 600129, 600477, 600478, 356345, 356349

An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures. The imaging system includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT. Also interferometric imaging and ranging techniques and fluorescent, Raman, two-photon, and diffuse wave imaging can be used. The forward scanning mechanisms include a cam attached to a motor, pneumatic devices, a pivoting device, piezoelectric transducers, electrostatic driven slides for substantially transverse scanning; counter-rotating prisms, and offset lenses are used for arbitrary scanning. The imaging system of the invention is applied to hand held probes including probes integrated with surgical probes, scalpels, scissors, forceps and biopsy instruments. Hand held probes include forward scanning lasers. The imaging system is also applicable to laparoscopes and endoscopes for diagnostc and therapeutic intervention in body orifices, canals, tubes, ducts, vessels and cavities of the body.

6501551, Dec 31, 2002

Oct 5, 1999

09/414293

Guillermo Tearney - Cambridge MA
Stephen A. Boppart - Boston MA
Brett E. Bouma - Boston MA
Mark Brezinski - Malden MA
Eric A. Swanson - Acton MA
James G. Fujimoto - Cambridge MA

Massachusetts Institute of Technology - Cambridge MA

G01B 902

356477, 356479

An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector.

6615062, Sep 2, 2003

May 31, 2001

09/871759

S. Eric Ryan - Hopkinton MA
Brett Bouma - Quincy MA
Guillermo J. Tearney - Cambridge MA
Simon Furnish - Louisville KY
Jing Tang - Allston MA
Andres Zuluaga - Boston MA

Infraredx, Inc. - Cambridge MA

A61B 500

600310, 600341, 3562431

The invention provides methods and apparatus to reference or normalize optical measurements, by removing or accounting for background factors and artifacts, such as motion artifacts, that arise during use of optical catheters.

6654630, Nov 25, 2003

May 31, 2001

09/871578

Andres F. Zuluaga - Boston MA
Brett Bouma - Quincy MA
Simon M. Furnish - Louisville KY
Guillermo J. Tearney - Cambridge MA
S. Eric Ryan - Hopkington MA
Jing Tang - Allston MA
Mark A. Griffin - Lexington KY

InfraReDx, Inc. - Cambridge MA

A61B 600

600476, 600473, 600478, 600407

A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having a distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally spaced apart from one another in the distal end of the catheter.

6701181, Mar 2, 2004

May 31, 2001

09/871770

Jing Tang - Allston MA
Guillermo J. Tearney - Cambridge MA
Brett E. Bouma - Quincy MA
S. Eric Ryan - Hopkinton MA
Simon Furnish - Louisville KY
Andres Zuluaga - Boston MA

InfraReDx, Inc. - Cambridge MA

A61B 600

600478, 600476, 385115, 385117, 385119, 606 13, 606 15, 606 16, 606 17

First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.

6706004, Mar 16, 2004

May 31, 2001

09/871771

Guillermo J. Tearney - Cambridge MA
Brett E. Bouma - Quincy MA
S. Eric Ryan - Hopkinton MA
Simon Furnish - Louisville KY
Jing Tang - Allston MA
Andres Zuluaga - Boston MA

Infraredx, Inc. - Cambridge MA

A61B 5103

600587, 600473, 604 9901, 606194

An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.