Inventors:
Yang Pan - Bellevue WA, US
Bradley Sevetson - Seattle WA, US
Jonathan Derry - Bainbridge Island WA, US
International Classification:
A61K048/00
A61K038/29
A61K031/663
C12Q001/68
C07H021/04
C12P021/02
C12N005/06
C12N009/64
US Classification:
514/044000, 514/012000, 514/102000, 435/006000, 435/069100, 435/226000, 435/320100, 435/325000, 536/023200
Abstract:
The present invention provides regulatory polynucleotides, vectors, and cells containing these polynucleotides. More particularly, this invention relates to regulatory polynucleotides derived from a regulatory region of the SOST gene, and the use of such polynucleotides for screening for agents that affect SOST regulation, for tissue-specific gene expression, and for other therapeutic and diagnostic applications. This invention further relates to methods of modulating bone mass in humans and other animals and for the treatment of osteoporosis and related bone disorders.