US Patent:
20060063168, Mar 23, 2006
Inventors:
Donna Albertson - Lafayette CA, US
Daniel Pinkel - Lafayette CA, US
Jane Fridyland - San Francisco CA, US
Bing Huey - San Francisco CA, US
Antoine Snijders - Antioch CA, US
Joe Gray - San Francisco CA, US
Anne Kallioniemi - Tampere, FI
Olli-Pekka Kallioniemi - Tampere, FI
Frederic Waldman - San Francisco CA, US
International Classification:
C12Q 1/68
Abstract:
The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).