US Patent:
20230056088, Feb 23, 2023
Inventors:
Adrian P. CRAWLEY - Toronto, CA
Rohan DHARMAKUMAR - Moorpark CA, US
James DUFFIN - Toronto, CA
Joseph Arnold FISHER - Thornhill, CA
David MIKULIS - Oakville, CA
Julien POUBLANC - Toronto, CA
Behzad SHARIF - Los Angeles CA, US
Olivia SOBCZYK - Etobicoke, CA
Kamil ULUDAG - Toronto, CA
Chau VU - Los Angeles CA, US
John WOOD - Los Angeles CA, US
Hsin-Jung YANG - Oakville, CA
International Classification:
G01R 33/28
A61B 5/055
A61B 5/00
A61B 5/026
A61B 5/145
G01R 33/50
G01R 33/58
Abstract:
Deoxyhemoglobin in a subject may be modulated to act as a contrast agent for use in magnetic resonance imaging. Sequential gas delivery may be applied to adjust the level of deoxyhemoglobin in the subject. A suitable magnetic resonance imaging (MRI) pulse sequence that is sensitive to magnetic field inhomogeneities, such as a blood-oxygen-level dependent (BOLD) sequence, may be used to detect deoxyhemoglobin as a contrast agent.