Bassem A Bejjani

7816123, Oct 19, 2010

Feb 11, 2005

11/057088

Lisa G. Shaffer - Colbert WA, US
Bassem A. Bejjani - Colbert WA, US

Signature Genomics-Perkin Elmer - Spokane WA

C12Q 1/68
C12Q 1/70
C12M 1/34
G01N 33/48

4352872, 435 5, 435 6, 702 19, 702 20

Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.

7910353, Mar 22, 2011

Feb 11, 2005

11/057088

Lisa G. Shaffer - Colbert WA, US
Bassem A. Bejjani - Colbert WA, US

Signature Genomic Laboratories - Spokane WA

C12Q 1/68
C12Q 1/70
C12M 1/34
G01N 33/48

4352872, 435 5, 435 6, 702 19, 702 20

Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.

20050202441, Sep 15, 2005

Dec 9, 2003

10/731419

Bassem Bejjani - Colbert WA, US
Todd Christensen - Deer Park WA, US

C12Q001/68
C07H021/04
C12P019/34

435006000, 435091200, 536024300

Subject matter includes design, synthesis, and propagation of synthetic and semi-synthetic reference nucleic acids and mixtures of reference nucleic acids for use in genetic tests, such as molecular screening, mutation testing, carrier testing, and diagnostic assays. In one implementation, methods are described for design, synthesis, and propagation of reference nucleic acid mixtures and a system is presented for using the mixtures.

20070238121, Oct 11, 2007

Mar 30, 2007

11/731424

Blake C. Ballif - Greenacres WA, US
Lisa G. Shaffer - Colbert WA, US
Bassem A. Bejjani - Colbert WA, US

C12Q 1/68
C12M 3/00

435 6, 4352872

Control nucleic acids and their method of use to simultaneously test for numerous genetic alterations that involve an unbalanced arrangement of chromosomes. One implementation increases reliability and accuracy by adding additional nucleic acid to test and/or reference samples. Clones representing segments insensitive to chromosomal rearrangements are placed in non-adjacent target areas of a microarray to avoid interfering hybridization reactions.

20090075835, Mar 19, 2009

Sep 16, 2008

12/211578

Bassem A. Bejjani - Spokane WA, US
Blake Charles Ballif - Greenacres WA, US
Lisa G. Shaffer - Spokane WA, US

SIGNATURE GENOMICS LABORATORIES, LLC - Spokane WA

C40B 30/04
C40B 40/08
C12Q 1/68

506 9, 506 17, 435 6

Methods for diagnosing the presence or absence of a genetic disorder in a patient are provided, wherein the genetic disorder is associated with a chromosomal abnormality at 1q41q42 and/or 16p11.2p12.2, and wherein the genetic disorder is not Fryns syndrome or congenital diaphragmatic hernia (CDH). Materials, such as microarrays for use in microarray CGH, and kits for use in such methods are also provided.

20100115421, May 6, 2010

Nov 5, 2008

12/265396

Bassem A. Bejjani - Spokane WA, US
Lisa G. Shaffer - Colbert WA, US
Blake Ballif - Greenacres WA, US
Brice Tebbs - Spokane WA, US
Kyle Sundin - Spokane WA, US

Signature Genomic Labs - Spokane WA

G06F 3/00
G06F 15/16
G06F 17/30
G06F 19/00

715751, 702 19, 707E17044

Techniques for allowing doctors and clinicians to upload genetic data associated with patients for comparison with previously-uploaded genetic data associated with other patients are described herein. These techniques may also allow doctors and clinicians to create notations associated with uploaded patient data. Both the previously-uploaded data as well as the created notations may be used by doctors and clinicians in attempting to diagnosis patients. That is, these techniques allow previously-acquired knowledge to be widely shared for the future benefit in attempting to detect genetic syndromes.

20100248983, Sep 30, 2010

Jun 10, 2010

12/797622

Lisa G. Shaffer - Colbert WA, US
Bassem A. Bejjani - Colbert WA, US

SIGNATURE GENOMICS LABORATORY - Spokane WA

C40B 30/04

506 9

Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.

20100248984, Sep 30, 2010

Jun 10, 2010

12/797623

Lisa G. Shaffer - Colbert WA, US
Bassem A. Bejjani - Colbert WA, US

SIGNATURE GENOMICS LABORATORY - Spokane WA

C40B 30/04

506 9

Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.