Bart L Staker

20040209344, Oct 21, 2004

Sep 9, 2003

10/659000

Michael Pantoliano - Boxford MA, US
M. Ryan - Littleton MA, US
Bart Staker - Kingston WA, US
G. Prasad - San Diego CA, US
Jin Tang - Canton MA, US
Saurabh Menon - Medford MA, US
Paul Towler - Gloucester MA, US
David Williams - London, GB
Martin Fisher - Wakefield, GB

C12N009/64
G06F019/00
G01N033/48
G01N033/50

435/226000, 702/019000

The invention relates to molecules or molecular complexes which comprise binding pockets of angiotensin-converting enzyme-related carboxypeptidase or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to angiotensin-converting enzyme-related carboxypeptidase protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising angiotensin-converting enzyme-related carboxypeptidase protein or angiotensin-converting enzyme-related carboxypeptidase protein complexes.

20050003502, Jan 6, 2005

Nov 14, 2001

09/993245

Alex Burgin - Bainbridge Island WA, US
Kathyrn Hjerrild - Bainbridge Island WA, US
Hidong Kim - Bainbridge Island WA, US
Bart Staker - Kingston WA, US
Lance Stewart - Bainbridge Island WA, US
Craig Behnke - Shoreline WA, US
Michael Feese - Seattle WA, US

Emerald BioStructures, Inc. - Brainbridge Island WA

G06F019/00
C12N009/99

435184000, 702019000

This invention relates to crystalline structures of the topoisomerase I and their use in designing new anti-cancer agents anti-viral agents and anti-microbial agents.

6599441, Jul 29, 2003

Jul 3, 2001

09/898907

Mary Ann Chrislip - Fredericksburg VA
Bart Staker - Silverdale WA

Emerald BioStructures, Inc. - Bainbridge Island WA

B01D 900

2522451, 436 4

In one aspect, the present invention provides sets of crystallization solutions that each comprise a crystallization solution set selected from the group of crystallization solution sets consisting of Crystallization Solution Set , Crystallization Solution Set , Crystallization Solution Set , Crystallization Solution Set and Crystallization Solution Set. In another aspect, the present invention provides kits that each comprise at least one crystallization plate and a Crystallization Solution Set of the invention.

20220214335, Jul 7, 2022

Feb 9, 2022

17/650443

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

G01N 33/536
C12Q 1/6825
G01N 21/64
G01N 1/30
H03M 13/15
G16B 40/00

Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.

20220206006, Jun 30, 2022

Mar 16, 2022

17/696631

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

G01N 33/58
G01N 27/414
C12Q 1/6837
C12Q 1/6825
C12Q 1/6804

Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

20210325397, Oct 21, 2021

Feb 17, 2021

17/178203

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

G01N 33/58
G01N 27/414
C12Q 1/6837
C12Q 1/6825
C12Q 1/6804

Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

20210087626, Mar 25, 2021

Oct 1, 2020

17/061023

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Michael David MCLAUGHLIN - San Jose CA, US
Bart Lee STAKER - Poulsbo WA, US

C12Q 1/6874
G16B 30/00
G16B 25/30
G06K 9/00
G06T 7/73

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

20210072233, Mar 11, 2021

Dec 26, 2019

16/727732

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

G01N 33/536
H03M 13/15
G01N 1/30
G01N 21/64
C12Q 1/6825
G16B 40/00

Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.