Inventors:
- Basel, CH
- South San Francisco, US
Avirup BOSE - Marlborough MA, US
Jacob CHA - South San Francisco CA, US
Nicole COOPER - Oakland CA, US
Darren FINKELSTEIN - South San Francisco CA, US
Linda GREENBAUM - Florham Park NJ, US
Johannes HULL - San Francisco CA, US
Susan Caroline KIRKLAND - Surrey, GB
Katerina LEFTHERIS - San Mateo CA, US
Maureen REILLY - Burlingame CA, US
Peter TARSA - Marshfield MA, US
Chinweike UKOMADU - Chestnut Hill MA, US
International Classification:
A61K 31/4162
A61K 31/4375
A61K 31/7048
A61K 45/06
A61P 1/16
Abstract:
The invention provides a pharmaceutical combination including an αvβintegrin inhibitor and at least one additional therapeutic agent for preventing, delaying or treating liver diseases or disorders. The additional therapeutic agent may be an SGLT1/2 inhibitor, among a diverse selection of agents. For example, the pharmaceutical combination includes (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) nonanoic acid (Compound 1) and at least one additional therapeutic agent.