Inventors:
Assunta S. Ng - Lansdale PA
Ralph J. Mancinelli - Harleysville PA
John P. Hennessey - Dublin PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3900
Abstract:
Novel combination of preservatives (methyl and propyl parabens, benzyl alcohol, and 2-phenoxyethanol) were found to pass antimicrobial testing according to USP, BP, and EP. The new preservatives were put into vaccines using L-histidine as a buffer to keep pH at 7. HPLC methods were developed to analyze these preservatives and their degradation products.