Antonis A Armoundas

6370412, Apr 9, 2002

Mar 28, 2000

09/535882

Antonis A. Armoundas - Cambridge MA
Andrew B. Feldman - Newport RI
Derin A. Sherman - Lincoln MA
Richard J. Cohen - Chestnut Hill MA

Massachusetts Institute of Technology - Cambridge MA

A61B 504

600373, 600515

This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhythmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.

7336995, Feb 26, 2008

Nov 19, 2002

10/299415

Antonis A. Armoundas - Cambridge MA, US
Richard J. Cohen - Chestnut Hill MA, US

Massachusetts Institute of Technology - Cambridge MA

A61N 1/362

607 9, 600513

Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of drug therapy and electrical impulses to the heart.

8249704, Aug 21, 2012

Jul 26, 2006

11/493466

Antonis A. Armoundas - Cambridge MA, US
Richard J. Cohen - Chestnut Hill MA, US

Massachusetts Institute of Technology - Cambridge MA

A61N 1/00

607 14, 607 18, 607 25

Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of electrical impulses to the heart during the absolute refractory period.

8265752, Sep 11, 2012

Apr 28, 2009

12/431558

Antonis A. Armoundas - Lincoln MA, US

The General Hospital Corporation - Boston MA

A61N 1/365

607 17, 607 14, 607 23, 607 9, 600500, 600509

A method for identifying a susceptibility of a subject to atrial-rhythm disturbances includes a) placing a plurality of sensors on the subject to measure a physiologic signal of the subject, and b) recording the physiologic signal from the sensor. The physiologic signal includes an atrial electrical activity of the subject. The method includes c) determining a beat-to-beat variability in the atrial electrical activity of the subject. The beat-to-beat variability includes alternans of electrocardiographic waveforms of a predetermined number of a sequence of heart beats. The method includes d) determining a susceptibility to atrial-rhythm disturbances of the subject using the beat-to-beat variability in the atrial electrical activity determined in step c), and e) generating a report of the susceptibility to atrial-rhythm disturbances of the subject.

8565876, Oct 22, 2013

Jun 8, 2012

13/492191

Antonis A. Armoundas - Lincoln MA, US
Richard J. Cohen - Chestnut Hill MA, US

Massachusetts Institute of Technology - Cambridge MA

A61N 1/00

607 14, 607 25

Method and apparatus for preventing heart rhythm disturbances by recording cardiac electrical activity, measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of electrical impulses to the heart during the absolute refractory period.

20090318983, Dec 24, 2009

Jul 6, 2007

12/373227

Antonis A. Armoundas - Lincoln MA, US
Ki H. Chon - Mount Sinai NY, US

A61N 1/362
A61M 37/00

607 3, 607 17

Method and apparatus for preventing autonomic system disturbances by recording physiological parameters, measuring beat-to-beat variability of these parameters, and using the measured beat-to-beat variability to control the delivery of drug therapy and electrical impulses to the heart.

20120316611, Dec 13, 2012

Nov 12, 2010

13/509390

Antonis Armoundas - Lincoln MA, US
Eric Weiss - Somerville MA, US

A61N 1/39

607 7

A method and apparatus are disclosed for preventing heart rhythm disturbances by optimally recording cardiac electrical activity, optimally measuring beat-to-beat variability in the morphology of electrocardiographic waveforms, and using the measured beat-to-beat variability to control the delivery of therapy to the heart.

63080931, Oct 23, 2001

Oct 7, 1999

9/413969

Antonis A. Armoundas - Cambridge MA
Andrew B. Feldman - Newport RI
Derin A. Sherman - Lincoln MA
Richard J. Cohen - Chestnut Hill MA

Massachusetts Institute of Technology - Cambridge MA

A61B 500

600509

This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhytmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.