US Patent:
20080200439, Aug 21, 2008
Inventors:
Alejandro M. Dopico - Cordova TN, US
Anna Nodarovna Bukiya - Memphis TN, US
Jianxi Liu - Memphis TN, US
Assignee:
University of Tennessee Research Foundation - Memphis TN
International Classification:
A61K 31/575
C12N 9/00
A61P 9/00
Abstract:
Methods and compositions are provided for modulating myocyte BK channel activity and for screening for modulators of BK channel activity. The methods and compositions are useful in the treatment of disorders where increasing myocyte BK channel activity can attenuate, revert or prevent the disorder. For example, the methods and compositions are useful for treating disorders ameliorated by increasing vasodilation and blood flow in a subject, in particular, increasing cerebral blood flow.
