Inventors:
Lanny S. Liebeskind - Atlanta GA, US
Wenting Wu - Decatur GA, US
Zhihui Zhang - Downers Grove IL, US
Hao Li - Decatur GA, US
Angus A. Lamar - Atlanta GA, US
Assignee:
EMORY UNIVERSITY - Atlanta GA
International Classification:
C12N 9/96
C07C 231/10
C07C 233/73
C08F 20/18
C07D 265/30
C07K 17/02
C07H 21/02
C07H 1/00
C07C 233/65
C07D 213/82
US Classification:
435188, 564187, 564184, 564186, 546316, 544176, 530300, 530322, 5303919, 536 231, 5361231, 5253304
Abstract:
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed. In another embodiment, the disclosure relates to mixing a thiolacid, a silylating agent, and an amine under conditions such that an amide is formed.