Inventors:
Jeffrey M. Blaney - San Diego CA, US
Andreas Gosberg - San Diego CA, US
Stefan N. Gradl - San Diego CA, US
Gavin Hirst - San Diego CA, US
Stephanie A. Hopkins - San Diego CA, US
Paul A. Sprengeler - San Diego CA, US
Ruo W. Steensma - San Diego CA, US
Johnny Uy - San Diego CA, US
Assignee:
SGX Pharmaceuticals, Inc. - San Diego CA
International Classification:
A61K 31/437
A61K 31/5377
A61K 31/497
A61P 35/00
C07D 491/147
C07D 471/04
US Classification:
514300, 546113, 546 64, 546119, 51421018, 514303, 5142345, 51425505, 514187, 544127, 544405
Abstract:
Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.