Althea K Talento

58372202, Nov 17, 1998

Sep 10, 1996

8/711576

J. Thomas Blake - Scotch Plains NJ
William P. Feeney - Yardley PA
Gloria C. Koo - Woodbridge NJ
Althea D. Talento - Convent Station NJ

Merck & Co., Inc. - Rahway NJ

A61K 4900

424 92

A method for analyzing the immunosuppressant activity of Kv1. 3 inhibitors using the mini- and micro-pig. These pig models have been found to have K. sub. v 1. 3 channels very similar to man both in function and setting of membrane potential of T-lymphocytes, and respond similarly in a mixed lymphocyte reaction (MLR) to the K. sub. v 1. 3 channel blockers. The mini-pig and micro-pig provide useful in vivo animal models for studying the immunosuppressant activity of Kv1. 3 channel blockers that would be expected to function in man.

62681559, Jul 31, 2001

Sep 10, 1996

8/711768

Gloria C. Koo - Woodbridge NJ
Mai P. Nguyen - Tinton Falls NJ
Althea D. Talento - Convent Station NJ

Merck & Co., Inc. - Rahway NJ

G01N 3353
G01N 33567

435 71

A method for objectively quantitating the cellular infiltration in a tissue biopsy of a warm-blooded animal using a capture ELISA method. This method also allows one to quantitate the cellular infiltration of a tissue biopsy corresponding to an inflammatory response. As such this invention has both research and clinical applications in the analysis of an inflammatory response, and the effectiveness of immunosuppresants in addressing the inflammation.