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Alexander L Klibanov

from Charlottesville, VA
Age ~67
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Also known as:
Alexander L Kilbanov
Phone and address:
639 Nettle Ct, Charlottesville, VA 22903
Related to:
Lazar G Klibanov, 96Jillian M Klibanov, 43Sergey A Klibanov, 43Galina B Diakova, 67
Connected to:
Flora Klibanov, 42Stacy D Klibanoff, 59Eric J Kliber, 41Wolfgang G Klich, 68Christine M Kliche, 52Vladimir I Klichko, 68Barbara J Klick, 70Danny S Klick, 64Jessica E Klick, 50Mark S Klick, 68

Alexander Klibanov Phones & Addresses

  • 639 Nettle Ct, Charlottesville, VA 22903
  • Charlottesvle, VA
  • 11720 Momarte Ln, Saint Louis, MO 63146
  • Pittsburgh, PA
  • Knoxville, TN

Work

Company: University of virginia Apr 2001 Position: Assoc professor

Industries

Research

Resumes

Resumes

Alexander Klibanov Photo 1

Assoc Professor

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Location:
Charlottesville, VA
Industry:
Research
Work:
University of Virginia
Assoc Professor

Publications

Wikipedia References

Alexander Klibanov Photo 2

Alexander Klibanov

Work:
Company:

University of Virginia faculty

Position:

Biologist

Education:
Academic degree:

Professor

Skills & Activities:
Preference:

Associate

Alexander Klibanov Photo 3

Alexander Klibanov

Work:
Company:

Massachusetts Institute of Technology faculty

Education:
Academic degree:

Member of the United States National Academy of Sciences • American academic • Professor

Us Patents

Multimodal Imaging Of Atherosclerotic Plaque Targeted To Lox-1

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US Patent:
8440167, May 14, 2013
Filed:
Oct 26, 2009
Appl. No.:
13/126029
Inventors:
George A. Beller - Charlottesville VA, US
David K. Glover - Charlottesville VA, US
Alexander L. Klibanov - Charlottesville VA, US
Craig H. Meyer - Charlottesville VA, US
Dayuan Li - Charlottesville VA, US
Amit Patel - Chicago IL, US
Christopher M. Kramer - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
A61K 49/16
A61K 51/10
A61K 51/12
A61K 39/395
A61B 5/055
C07K 16/00
US Classification:
424 137, 424 149, 424 153, 424 9321, 4241431
Abstract:
The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.

System For Treatment And Imaging Using Ultrasonic Energy And Microbubbles And Related Method Thereof

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US Patent:
8622911, Jan 7, 2014
Filed:
Oct 24, 2008
Appl. No.:
12/739128
Inventors:
John A. Hossack - Charlottesville VA, US
Brian R. Wamhoff - Charlottesville VA, US
Alexander L. Klibanov - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
A61B 8/00
A61M 31/00
US Classification:
600439, 604500, 424 952
Abstract:
A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.

Microbubble Compositions, And Methods For Preparing And Using Same

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US Patent:
20050260189, Nov 24, 2005
Filed:
Jul 11, 2003
Appl. No.:
10/511383
Inventors:
Alexander Klibanov - Charlottesville VA, US
Klaus Ley - Charlottesville VA, US
Joshua Rychak - Charlottesville VA, US
International Classification:
A61K039/395
US Classification:
424130100
Abstract:
Described are microbubble compositions including microbubbles having membranes that incorporate modified surface features that may be useful, for example, in facilitating binding to a target surface or substance. The surface features may include non-spherical attributes such as crenations, folds, projections, or wrinkles, which can increase the deformability of the microbubble membrane. Such microbubble compositions can be incorporated into targeted ultrasound contrast agents and methodologies. Methods for preparing modified microbubble compositions include providing microbubbles having spherical membranes, and converting the spherical membranes to non-spherical membranes having surface features as mentioned above. Targeting substances can be incorporated into the membranes before or after their conversion from spherical to non-spherical forms.

Deposit Contrast Agents And Related Methods Thereof

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US Patent:
20070059247, Mar 15, 2007
Filed:
Aug 29, 2006
Appl. No.:
11/511721
Inventors:
Jonathan Lindner - Portland OR, US
Beat Kaufmann - Portland OR, US
Alexander Klibanov - Charlottesville VA, US
International Classification:
A61K 49/22
US Classification:
424009520
Abstract:
A method for generating an enhanced ultrasound image comprises intravenously administering to a subject a plurality of microbubbles of sufficient diameter to lodge in the microvasculature of a subject. An ultrasound image of a portion of the subject is generated wherein the image is enhanced by one or more of the administered microbubbles that has lodged in the microvasculature of the imaged portion. An ultrasound contrast media composition comprises a plurality of gas filled microbubbles. At least about 5% of the microbubbles have a diameter of at least about 4 microns (μm), and wherein the composition is suitable for intravenous administration. The administered microbubbles are of sufficient diameter to lodge in the microvasculature of a subject and can be used enhance ultrasound images small animal subjects including mice, rats and rabbits. The described methods and compositions can be used to enhance ultrasound images produced using high frequency ultrasound.

Tumor Treatment Using Ultrasound Cavitation

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US Patent:
20120029397, Feb 2, 2012
Filed:
Apr 2, 2010
Appl. No.:
13/262924
Inventors:
Chien Ting Chin - Tarrytown NY, US
Christopher Stephen Hall - Hopewell Junction NY, US
Alexander L. Klibanov - Charlottesville VA, US
Assignee:
THE UNIVERSITY OF VIRGINIA - CHARLOTTESVILLE VA
KONINKLIJKE PHILIPS ELECTRONICS N.V. - EINDHOVEN
International Classification:
A61N 7/00
US Classification:
601 2
Abstract:
Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses () of energy to respective focal points () at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm () in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.

Systems And Methods For Ultrasound Imaging And Insonation Of Microbubbles

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US Patent:
20120209116, Aug 16, 2012
Filed:
Jul 21, 2010
Appl. No.:
13/386391
Inventors:
John A. Hossack - Charlottesville VA, US
Brian R. Wamhoff - Charlottesville VA, US
Alexander L. Klibanov - Charlottesville VA, US
Johnny Chen - Chantilly VA, US
Brent A. French - Charlottesville VA, US
International Classification:
A61M 37/00
A61K 49/22
A61B 8/00
US Classification:
600439, 604 23, 604 22, 424 952
Abstract:
A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.

Methods And Compositions For Two-Stage Microbubble Delivery Of Active Agents

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US Patent:
20220218850, Jul 14, 2022
Filed:
Jan 13, 2022
Appl. No.:
17/574790
Inventors:
- Richmond VA, US
Luni Emdad - Richmond VA, US
Praveen Bhoopathi - Richmond VA, US
Anjan K. Pradhan - Richmond VA, US
Swadesh K. Das - Richmond VA, US
Alexander L. Klibanov - Charlottesville VA, US
International Classification:
A61K 49/22
A61K 45/06
A61K 31/7115
Abstract:
In various aspects, the present disclosure provides methods, compositions, and kits for treating a target tissue with one or more active agents. In embodiments, delivering an active agent to a target tissue comprises administration of microbubbles and ultrasound.

Compositions And Methods For High-Sensitivity Immunoassays

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US Patent:
20210373011, Dec 2, 2021
Filed:
Aug 7, 2017
Appl. No.:
16/322679
Inventors:
- Charlottesville VA, US
Alexander L. KLIBANOV - Charlottesville VA, US
Bruce D. GAYLINN - Louisa VA, US
International Classification:
G01N 33/543
G01N 33/68
Abstract:
Lanthanide chelate lipid nanoparticles, and methods of their synthesis and use are described. Biological molecules labeled with the lipid nanoparticles, useful in bioaffinity assays with improved sensitivities are also described.

Wikipedia

Alexander Klibanov

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Alexander Klibanov could mean: Alexander L. (Sasha) Klibanov an Associate Professor in the Division of Cardiovascular Medicine and Department of Biomedical ...

Isbn (Books And Publications)

Enzyme Engineering 9

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Author

Alexander M. Klibanov

ISBN #

0897664809

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Alexander L Klibanov from Charlottesville, VA, age ~67 Get Report