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Alessandra Bartolozzi

from Glenside, PA
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Also known as:
Gavin Loscalzo
Connected to:
Alize L Bartolone, 46Alvin P Bartolo, 80Andrew P Bartolotta, 40Angel C Bartolome, 75Anthony L Bartolotta, 74Antonio G Bartolome, 73Antonio G Bartolomeo, 28Bart T Bartolome, 69Blanca R Bartolome, 64Camille Bartolome, 34

Alessandra Bartolozzi Phones & Addresses

  • Glenside, PA
  • New Haven, CT
  • 60 College Ave, Somerville, MA 02144 (617) 776-0471

Publications

Us Patents

Pharmacokinetically Improved Compounds

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US Patent:
8357693, Jan 22, 2013
Filed:
Mar 27, 2006
Appl. No.:
11/887218
Inventors:
Alessandra Bartolozzi - Somerville MA, US
Stewart Campbell - Framingham MA, US
Hope Foudoulakis - Framingham MA, US
Brian Kirk - Sudbury MA, US
Siya Ram - Winchester MA, US
Paul Sweetnam - Marblehead MA, US
Assignee:
Surface Logix, Inc. - Brighton MA
International Classification:
A01N 43/54
A61K 31/517
US Classification:
51426623, 544284
Abstract:
The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Inhibitors Of Microsomal Triglyceride Transfer Protein And Apo-B Secretion

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US Patent:
20070027183, Feb 1, 2007
Filed:
Apr 19, 2006
Appl. No.:
11/407500
Inventors:
Alessandra Bartolozzi - Somerville MA, US
Stewart Campbell - Framingham MA, US
Hope Foudoulakis - Framingham MA, US
Enoch Kim - Boston MA, US
Paul Sweetnam - Marblehead MA, US
Yingfei Yang - Belmont MA, US
Assignee:
Surface Logix, Inc. - Brighton MA
International Classification:
A61K 31/4709
C07D 401/02
US Classification:
514310000, 546146000, 546148000
Abstract:
The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.

Rho Kinase Inhibitors

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US Patent:
20120202793, Aug 9, 2012
Filed:
Mar 9, 2010
Appl. No.:
13/255879
Inventors:
Paul Sweetnam - Marblehead MA, US
Alessandra Bartolozzi - Norwalk CT, US
Anthony Stewart Campbell - Framingham MA, US
Bridget Cole - Quincy MA, US
Hope Foudoulakis - Framingham MA, US
Brian Kirk - Sudbury MA, US
Hemalatha Seshadri - Waltham MA, US
Siya Ram - Winchester MA, US
International Classification:
A61K 31/551
C07D 239/94
A61P 3/08
C07D 413/14
C07D 243/08
A61P 3/04
A61K 31/517
A61K 31/5377
US Classification:
514218, 51426623, 544293, 5142345, 544119, 51425217, 540575
Abstract:
The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins.

Inhibitors Of Microbially Induced Amyloid

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US Patent:
20230113225, Apr 13, 2023
Filed:
Aug 4, 2022
Appl. No.:
17/880996
Inventors:
- Woburn MA, US
Bridget Cole - Quincy MA, US
Alessandra Bartolozzi - Norwalk CT, US
Assignee:
Axial Therapeutics, Inc. - Woburn MA
International Classification:
C07D 215/56
C07D 333/68
Abstract:
The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathics such as Parkinson's Disease.

Inhibitors Of Microbially Induced Amyloid

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US Patent:
20230103887, Apr 6, 2023
Filed:
Aug 4, 2022
Appl. No.:
17/881044
Inventors:
- Woburn MA, US
Bridget Cole - Quincy MA, US
Alessandra Bartolozzi - Norwalk CT, US
Assignee:
Axial Therapeutics, Inc. - Woburn MA
International Classification:
C07D 215/56
C07D 333/68
Abstract:
The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.

Inhibitors Of Microbially Induced Amyloid

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US Patent:
20200290970, Sep 17, 2020
Filed:
Aug 6, 2018
Appl. No.:
16/636511
Inventors:
- Waltham MA, US
Bridget Cole - Quincy MA, US
Alessandra Bartolozzi - Norwalk CT, US
Assignee:
Axial Biotherapeutics, Inc. - Waltham MA
International Classification:
C07D 215/56
C07D 333/68
Abstract:
The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.

Inhibitors Of Microsomal Triglyceride Transfer Protein And Apo-B Secretion

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US Patent:
20160039765, Feb 11, 2016
Filed:
Mar 17, 2015
Appl. No.:
14/660453
Inventors:
Alessandra Bartolozzi - Somerville MA, US
Stewart Campbell - Framingham MA, US
Hope Foudoulakis - Framingham MA, US
Enoch Kim - Boston MA, US
Paul Sweetnam - Marblehead MA, US
Yingfei Yang - Belmont MA, US
International Classification:
C07D 217/06
A61K 31/4725
C07D 417/04
A61K 45/06
A61K 31/472
Abstract:
The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.
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Alessandra Bartolozzi from Glenside, PA Get Report