Inventors:
Alanna Schepartz Shrader - Wilton CT, US
Jason W.K. Chin - San Diego CA, US
Reena Zutshi - New Haven CT, US
Stacey E. Rutledge - New Haven CT, US
Tanya L. Schneider - Harpswell ME, US
Heather M. Volkman - New Haven CT, US
Assignee:
Yale University - New Haven CT
International Classification:
C07K 2/00
C07K 14/765
C07K 16/00
C07K 1/107
US Classification:
530300, 530350, 530363, 5303911, 530402
Abstract:
The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.