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Alan J Kraker

from Ann Arbor, MI
Age ~68
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Also known as:
Alan John Kraker, Alan R Kraker, Alan A Kraker
Phone and address:
2515 Prairie St, Ann Arbor, MI 48105
(734) 996-1074
Related to:
Toni Van DrunenCatherine KrakerGeoffrey A Kraker, 39Beverly J Kraker, 69Peter J Kraker, 36
Connected to:
Darren E Kraker, 51Randy A Kraker, 71Tihomil Kraker, 33Vera B Kraker, 85Loretta Krakie, 59Brian L Kraklau, 33Delphine Krakoff, 53Mary E Krakora, 66Ronald F Krakosky, 74Dmitri Krakovsky, 92

Alan Kraker Phones & Addresses

  • 2515 Prairie St, Ann Arbor, MI 48105 (734) 996-1074 (734) 996-1968 (734) 996-1442
  • Houston, TX
  • 6658 Scenic Shores Dr, Holland, MI 49423 (616) 335-3019
  • Shorewood, WI
  • 2515 Prairie St, Ann Arbor, MI 48105 (734) 476-3081

Work

Company: Pfizer 2003 to 2008 Position: Director

Education

Degree: High school graduate or higher

Skills

Pharmaceutical Industry • Clinical Development • Oncology • Drug Development • Drug Discovery • Biotechnology • Regulatory Submissions • Pharmacology • Clinical Trials • Cro • Gcp • Regulatory Affairs • Biomarkers • Life Sciences • Lifesciences • Good Clinical Practice • Cro Management

Emails

b***[email protected]

Industries

Pharmaceuticals

Resumes

Resumes

Alan Kraker Photo 1

Alan Kraker

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Location:
Ann Arbor, MI
Industry:
Pharmaceuticals
Work:
Pfizer 2003 - 2008
Director
Pfizer 2003 - 2008
Senior Director
Pfizer 2000 - 2003
Associate Research Fellow
Skills:
Pharmaceutical Industry
Clinical Development
Oncology
Drug Development
Drug Discovery
Biotechnology
Regulatory Submissions
Pharmacology
Clinical Trials
Cro
Gcp
Regulatory Affairs
Biomarkers
Life Sciences
Lifesciences
Good Clinical Practice
Cro Management

Publications

Us Patents

Bicyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The Epidermal Growth Factor Receptor Family

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US Patent:
6455534, Sep 24, 2002
Filed:
Apr 2, 2001
Appl. No.:
09/824606
Inventors:
Alexander James Bridges - Saline MI
William Alexander Denny - Auckland, NZ
David Fry - Ypsilanti MI
Alan Kraker - Ann Arbor MI
Robert Frederick Meyer - Ann Arbor MI
Gordon William Rewcastle - Auckland, NZ
Andrew Mark Thompson - Auckland, NZ
Assignee:
Warner-Lambert Company - Ann Arbor MI
International Classification:
A61K 31519
US Classification:
514258, 514267, 5142245, 5142285, 5142298, 5142342, 5142345, 514250, 51425216, 544251, 544271, 544 34, 544 61, 544101, 544117
Abstract:
Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where: one of A or E is nitrogen, with remaining atoms carbon; X=O, S, NH or NR , such that R =lower alkyl (1-4 carbon atoms), OH, NH , lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.

Tricyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The Epidermal Growth Factor Receptor Family

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US Patent:
6596726, Jul 22, 2003
Filed:
Mar 6, 1997
Appl. No.:
08/811803
Inventors:
Alexander James Bridges - Saline MI
William Alexander Denny - Auckland, NZ
David Fry - Ypsilanti MI
Alan Kraker - Ann Arbor MI
Robert Frederick Meyer - Ann Arbor MI
Gordon William Rewcastle - Auckland, NZ
Andrew Mark Thompson - Auckland, NZ
Howard Daniel Hollis Showalter - Ann Arbor MI
Assignee:
Warner Lambert Company - Morris Plains NJ
International Classification:
A61K 31505
US Classification:
514267, 544250
Abstract:
Described are compounds of the following formula and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: wherein the formula terms are described in the specification and wherein the members in the aforementioned structure are defined in the specification.

Inhibitors Of Checkpoint Kinases (Wee1 And Chk1)

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US Patent:
7094798, Aug 22, 2006
Filed:
Apr 25, 2003
Appl. No.:
10/424228
Inventors:
Richard John Booth - Ann Arbor MI, US
Ellen Myra Dobrusin - Ann Arbor MI, US
Alan Kraker - Ann Arbor MI, US
Lorna Helen Mitchell - Dexter MI, US
William Alexander Denny - Auckland, NZ
Jeffrey Bruce Smaill - Auckland, NZ
Andrew Mark Thompson - Auckland, NZ
Florence Oliver Joseph McCarthy - Auckland, NZ
Ho Huat Lee - Auckland, NZ
Brian Desmond Palmer - Auckland, NZ
Assignee:
Pfizer Inc - New York NY
International Classification:
A61K 31/403
C07D 209/88
US Classification:
514410, 548420
Abstract:
This invention relates to pyrrolocarbazole derivatives according formula I wherein R, R, R, R, R, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1.

Bicyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The Epidermal Growth Factor Receptor Family

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US Patent:
20030186987, Oct 2, 2003
Filed:
Jul 24, 2002
Appl. No.:
10/201808
Inventors:
Alexander Bridges - Saline MI, US
William Denny - Auckland, NZ
David Fry - Ypsilanti MI, US
Alan Kraker - Ann Arbor MI, US
Robert Meyer - Ann Arbor MI, US
Gordon Rewcastle - Auckland, NZ
Andrew Thompson - Auckland, NZ
International Classification:
A61K031/519
A61K031/525
C07D487/02
US Classification:
514/248000, 514/251000, 514/262100, 544/236000, 544/258000, 544/255000
Abstract:
Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: where: at least two of A-E are nitrogen, with the remaining atom(s) carbon; X NH or NR, such that R lower alkyl (1-4 carbon atoms), OH, NH, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms); n=0, 1, 2. The remaining substituents are described in detail in the specification.

Modified Wee1, Crystals Of Peptide: Inhibitor Complexes Containing Such Modified Wee1, And Methods Of Use Thereof

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US Patent:
20050037476, Feb 17, 2005
Filed:
May 4, 2004
Appl. No.:
10/837652
Inventors:
Edward Baker - Takapuna, NZ
Richard Booth - Ann Arbor MI, US
Alan Kraker - Ann Arbor MI, US
Daniel Ortwine - Saline MI, US
James Dickson - Beachhaven, NZ
Ivan Ivanovic - Ellerslie, NZ
Christopher Squire - Devonport, NZ
International Classification:
G06F019/00
G01N033/48
G01N033/50
C12N009/99
C12N009/22
US Classification:
435184000, 435199000, 702019000
Abstract:
Modified Wee1 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: inhibitor complexes have been discovered. The three-dimensional structure of Wee1, including the ATP substrate binding site, and uses of this information in the design and screening of compounds that may associate with Wee1, or peptides structurally related thereto, have also been discovered.

Inhibitors Of Checkpoint Kinases (Wee1 And Chk1)

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US Patent:
20050250836, Nov 10, 2005
Filed:
May 2, 2005
Appl. No.:
11/120746
Inventors:
Richard Booth - Ann Arbor MI, US
Ho Lee - Epsom, NZ
Alan Kraker - Ann Arbor MI, US
Daniel Ortwine - Saline MI, US
Brian Palmer - Glendene, NZ
Derek Sheehan - Dexter MI, US
Peter Toogood - Ann Arbor MI, US
International Classification:
A61K031/407
C07D487/02
US Classification:
514411000, 548429000
Abstract:
This invention relates to substituted indacene molecules that specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 and are useful in the treatment of proliferative disorders.

Bicyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The Epidermal Growth Factor Receptor Family

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US Patent:
62654101, Jul 24, 2001
Filed:
Nov 13, 1998
Appl. No.:
9/191163
Inventors:
Alexander James Bridges - Saline MI
William Alexander Denny - Pakuranga, NZ
David Fry - Ypsilanti MI
Alan Kraker - Ann Arbor MI
Robert Frederick Meyer - Ann Arbor MI
Gordon William Rewcastle - Manurewa, NZ
Andrew Mark Thompson - Mount Eden, NZ
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31519
C07D48704
US Classification:
514258
Abstract:
Described are compositions and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: ##STR1## where: any two continguous positions in positions A-E taken together can be a single heteroatom selected from the group consisting of nitrogen, oxygen or sulfur, in which case the other two remaining atoms must be carbon; the remaining substituents are disclosed in the specification.

Bicyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The Epidermal Growth Factor Receptor Family

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US Patent:
56543077, Aug 5, 1997
Filed:
Dec 23, 1994
Appl. No.:
8/358351
Inventors:
Alexander James Bridges - Saline MI
William Alexander Denny - Pakuranga, NZ
David Fry - Ypsilanti MI
Alan Kraker - Ann Arbor MI
Robert Frederick Meyer - Ann Arbor MI
Gordon William Rewcastle - Manurewa, NZ
Andrew Mark Thompson - Mount Eden, NZ
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31505
C07D23970
C07D48700
US Classification:
514258
Abstract:
Novel 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinase are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.
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Alan J Kraker from Ann Arbor, MI, age ~68 Get Report