Inventors:
Tsutomu Akama - Sunnyvale CA, US
Akira Asai - San Diego CA, US
Tsutomu Agatsuma - Machida, JP
Shinji Nara - Sunto-gun, JP
Yoshinori Yamashita - Sunto-gun, JP
Tamio Mizukami - Chiyoda-Ku, JP
Shun-ichi Ikeda - Machida, JP
Yutaka Saitoh - Sunto-gun, JP
Yutaka Kanda - Sunto-gun, JP
Assignee:
Kyowa Hakko Kogyo Co., Ltd. - Tokyo
International Classification:
A61K031/403
A61K031/4453
C07D209/52
C07D401/06
US Classification:
514413, 514323, 548453, 546201
Abstract:
UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein Rrepresents hydrogen, lower alkyl, etc. ; Rrepresents hydrogen, or is combined with Rto represent a bond, etc. , or is combined with Rto represent —O(C═O)—, etc. ; Rrepresents hydrogen, etc. , or is combined with Rto represent a bond, etc. ; Rrepresents hydrogen, etc. , or is combined with Rto represent —(C═O)O—, etc. ; Rrepresents hydrogen or is combined with Rto represent a bond; Rrepresents hydrogen, etc. , or is combined with Rto represent a bond; Rrepresents hydrogen or is combined with Rto represent ═O; Rrepresents hydroxy or is combined with Rto represent ═O; represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.