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Akinleye C Alabi

from Ithaca, NY
Age ~43
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Also known as:
Christopher A Alabi, Akinley Alabi, Christopher A Aladi, Christophe Alabi, Alabi A Chrisopher
Related to:
Kale A Mcginnis, 32Renee Hendrickson, 54Christi Mcculler, 48Carolyn Hendrickson, 33Elizabeth Hendrickson, 53Wayne A Ginnis, 98
Connected to:
Atinuke I Alabi, 55Babatunde A Alabi, 68Catherine B Alabi, 32Esther Alabi, 69Folashade R Alabi, 43Jessica Alabi, 125Lateefat A Alabi, 57Mario L Alabi, 50Muftau M Alabi, 68Segun D Alabi, 65

Akinleye Alabi Phones & Addresses

  • Ithaca, NY
  • Pasadena, CA
  • Cambridge, MA
  • New York, NY

Publications

Us Patents

Carrier Nanoparticles And Related Compositions, Methods And Systems

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US Patent:
8557292, Oct 15, 2013
Filed:
Aug 12, 2009
Appl. No.:
12/540319
Inventors:
Mark E. Davis - Pasadena CA, US
Akinleye Alabi - Cambridge MA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
A61K 9/14
US Classification:
424489
Abstract:
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Click Chemistry Surface Functionalization For Resonant Micro-Cavity Sensors

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US Patent:
20090214755, Aug 27, 2009
Filed:
Nov 26, 2008
Appl. No.:
12/324605
Inventors:
Andrea M. Armani - Pasadena CA, US
Akinleye C. Alabi - Pasadena CA, US
Mark E. Davis - Pasadena CA, US
Richard C. Flagan - Pasadena CA, US
Scott E. Fraser - La Canada CA, US
International Classification:
B05D 3/00
US Classification:
427 213
Abstract:
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

Click Chemistry Surface Functionalization For Resonant Micro-Cavity Sensors

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US Patent:
20120107177, May 3, 2012
Filed:
Jan 9, 2012
Appl. No.:
13/346484
Inventors:
Andrea M. Armani - Pasadena CA, US
Akinleye C. Alabi - Pasadena CA, US
Mark E. Davis - Pasadena CA, US
Richard C. Flagan - Pasadena CA, US
Scott E. Fraser - La Canada CA, US
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA
International Classification:
G01N 33/53
US Classification:
422 69
Abstract:
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

Amino Acid-, Peptide-And Polypeptide-Lipids, Isomers, Compositions, And Uses Thereof

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US Patent:
20130158021, Jun 20, 2013
Filed:
Oct 26, 2012
Appl. No.:
13/662002
Inventors:
Massachusetts Institute of Technology - Cambridge MA, US
Kevin Thomas Love - Boston MA, US
Robert S. Langer - Newton MA, US
Daniel Griffith Anderson - Sudbury MA, US
Delai Chen - Cambridge MA, US
Yi Chen - Cambridge MA, US
Arturo Jose Vagas - Cambridge MA, US
Akinleye Alabi - Cambridge MA, US
Yunlong Zhang - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C07C 323/58
C12Q 1/02
C07D 241/08
C12N 15/87
C07D 487/04
C07D 413/06
C07C 279/14
C07C 229/12
C07C 229/24
C07D 209/24
C07D 233/64
C07D 265/32
G01N 33/15
C07D 403/06
US Classification:
5142305, 506 9, 506 12, 506 10, 435375, 544385, 435455, 544349, 544373, 562560, 560168, 562567, 560170, 562568, 562557, 560153, 548496, 5483391, 544162, 544173, 544171, 544158, 544143, 544174, 544105, 544224, 544238, 544240, 544239, 544319, 544320, 544321, 5142308, 514565, 514551, 514561, 514562, 514550, 514419
Abstract:
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:wherein m, n, p, R′, R, R, R, R, R, R, Z, W, Y, and Z are as defined herein.

Carrier Nanoparticles And Related Compositions, Methods And Systems

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US Patent:
20130209448, Aug 15, 2013
Filed:
Mar 28, 2013
Appl. No.:
13/852397
Inventors:
California Institute of Technology - , US
Akinleye Alabi - Cambridge MA, US
Assignee:
California Institute of Technology - Pasadena CA
International Classification:
A61K 9/14
US Classification:
4241301, 514 44 R, 514 44 A
Abstract:
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Amino Acid-, Peptide- And Polypeptide-Lipids, Isomers, Compositions, And Uses Thereof

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US Patent:
20200330501, Oct 22, 2020
Filed:
May 5, 2020
Appl. No.:
16/867291
Inventors:
- Cambridge MA, US
Kevin Love - Boston MA, US
Robert S. Langer - Newton MA, US
Daniel Griffith Anderson - Framingham MA, US
Delai Chen - Cambridge MA, US
Yi Chen - Cambridge MA, US
Arturo Jose Vegas - Belmont MA, US
Akinleye C. Alabi - Ithaca NY, US
Yunlong Zhang - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 31/7105
C07D 233/64
C07D 403/06
C07D 241/08
C07C 229/12
C07C 229/22
C07C 229/26
C07D 487/06
C07D 207/16
C07D 209/20
C07C 271/22
C07C 229/36
C07C 237/08
C07C 237/12
C12N 15/88
C12N 15/87
C07C 229/24
C07C 279/14
C07C 323/58
C07D 209/24
C07D 265/32
C07D 413/06
C07D 487/04
C12Q 1/02
G01N 33/15
A61K 31/711
A61K 47/22
Abstract:
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:wherein m, n, p, R′, R, R, R, R, R, R, Z, W, Y, and Z are as defined herein.

Carrier Nanoparticles And Related Compositions, Methods And Systems

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US Patent:
20190314520, Oct 17, 2019
Filed:
Jul 1, 2019
Appl. No.:
16/458614
Inventors:
- Pasadena CA, US
Akinleye Alabi - Cambridge MA, US
International Classification:
A61K 47/69
C08G 59/40
A61K 47/59
A61K 9/51
C08G 69/40
C12N 15/113
A61K 47/54
A61K 31/704
C08G 69/48
A61K 9/14
A61K 31/4745
A61K 31/713
A61K 31/337
C08G 65/337
A61K 47/64
Abstract:
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Amino Acid-, Peptide- And Polypeptide-Lipids, Isomers, Compositions, And Uses Thereof

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US Patent:
20190076462, Mar 14, 2019
Filed:
Sep 10, 2018
Appl. No.:
16/126897
Inventors:
- Cambridge MA, US
Kevin Thomas Love - Boston MA, US
Robert S. Langer - Newton MA, US
Daniel Griffith Anderson - Framingham MA, US
Delai Chen - Cambridge MA, US
Yi Chen - Cambridge MA, US
Arturo Jose Vegas - Belmont MA, US
Akinleye C. Alabi - Ithaca NY, US
Yunlong Zhang - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 31/7105
C07C 237/08
G01N 33/15
C07C 271/22
C07C 237/12
C12Q 1/02
C07C 229/24
C07C 279/14
C07D 209/20
C07D 207/16
C07D 487/06
C07C 229/26
C07C 229/22
C07C 229/12
C07D 241/08
C07D 403/06
C07D 233/64
C12N 15/88
C12N 15/87
A61K 47/22
A61K 31/711
C07D 265/32
C07D 413/06
C07D 487/04
C07C 323/58
C07D 209/24
C07C 229/36
Abstract:
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein:wherein m, n, p, R′, R, R, R, R, R, R, Z, W, Y, and Z are as defined herein.
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Akinleye C Alabi from Ithaca, NY, age ~43 Get Report