Inventors:
- Baltimore MD, US
- Seattle WA, US
Adeline Hajjar - Seattle WA, US
International Classification:
C12P 19/12
C07H 11/04
C12P 19/44
C12P 19/26
A61K 31/739
A61K 39/39
A61K 39/02
Abstract:
Embodiments of the disclosure provide for unique lipooligosaccharide/lipid A-based mimetics for use as adjuvants. Methods of generating lipooligosaccharide/lipid A-based mimetics are provided that utilize recombinantly engineered bacteria to produce the mimetics, including, for example, addition of one or more particular enzymes such as acyltransferases, deacylases, phosphatases, or glycosyltransferases.