US Patent:
20170368044, Dec 28, 2017
Inventors:
- Basel, CH
Abdel Saci - Arlington MA, US
K. Gary J. Vanasse - Chestnut Hill MA, US
Joseph Daniel Growney - Reading MA, US
International Classification:
A61K 31/444
A61K 31/4439
A61K 31/519
A61K 45/06
Abstract:
The present invention relates to a Pim kinase inhibitor compound that can be used alone or in a pharmaceutical combination. One such combination comprises (a) a JAK inhibitor compound, (b) a Pim kinase inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of a myeloid neoplasm or leukemia; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of myeloid neoplasm or leukemia; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a mammal, especially a human.