Robert Lewis Chapman

6627461, Sep 30, 2003

Apr 18, 2001

09/837898

Robert G. Chapman - Burlingame CA
John Hefti - San Francisco CA
Barrett J. Bartell - Pacifica CA
Mark A. Rhodes - Redwood City CA
Min Zhao - Foster City CA
Tyler Palmer - San Francisco CA

Signature Bioscience, Inc. - San Francisco CA

G01N 33536

436536, 422 8201, 435 4, 435 6, 435 71, 435 72, 435 792, 4352871, 4352872, 436149, 436150, 436151, 436517, 436518, 436524, 436805, 436806

The present invention provides a method for detecting a molecular event, comprising (1) applying an electromagnetic test signal to a sample in which a molecular event is being detected, whereby the sample interacts with and modulates the test signal to produce a modulated test signal, and (2) detecting the modulated test signal, wherein the applying and detecting take place in a temperature-controlled environment, wherein the temperature-controlled environment comprises the sample, a radiating portion of a signal generating circuit, and a receiving portion of a signal detection circuit and wherein the applying and detecting take place in the environment at a temperature controlled to within Â0. 5Â C.

7011948, Mar 14, 2006

Jul 17, 2002

10/198465

Robert G. Chapman - Burlingame CA, US
Pejman Ghanouni - Menlo Park CA, US
Igor Shmulevich - San Ramon CA, US
David Balaban - San Jose CA, US
Joseph A. Heanue - Halfmoon Bay CA, US
Andrew P. May - San Francisco CA, US
Nikolai Sharkov - San Francisco CA, US

MDS Sciex - South San Francisco CA

C12Q 1/68
C12P 19/34
G01N 15/06
G01N 33/00
B01L 3/00

435 6, 435 71, 435 721, 435 4, 4352872, 4352887, 436501, 436518, 436524, 436527, 436528, 436535, 422 681, 422 81, 422 99

Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i. e. , properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.

7276286, Oct 2, 2007

Jul 17, 2001

09/907551

Robert G. Chapman - Burlingame CA, US
Emanuele Ostuni - Cambridge MA, US
Michael N. Liang - Somerville MA, US
Lin Yan - East Brunswick NJ, US
George M. Whitesides - Newton MA, US

President & Fellows of Harvard College - Cambridge MA

B32B 9/04
B32B 15/04
B32B 15/08
B32B 27/34

4284111, 428332, 428336, 428338, 428339, 428457, 428458, 4284744

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

7302512, Nov 27, 2007

Dec 9, 2005

11/297992

Andrew Currid - Alameda CA, US
Robert William Chapman - Mountain View CA, US

Nvidia Corporation - Santa Clara CA

G06F 9/46

710268, 710260, 710261, 710263, 710 48

A computer device, an input/output (“I/O”) communication subsystem, a chipset and a method are disclosed for implementing interrupt message packets to facilitate peer-to-peer communications between a device controller and a coprocessor. Advantageously, the various embodiments of the invention obviate a requirement for specialized circuitry on a motherboard to establish peer-to-peer communications. In one embodiment, an I/O communication subsystem includes a bus interface for coupling the I/O communication subsystem to a general-purpose bus. It also includes a device controller being configured to generate an interrupt as an interrupt message packet for a coprocessor, which, in turn, interrupts processing functions that otherwise are performed by the host processor. The device controller can reside either internal or external to the I/O communication subsystem.

7487371, Feb 3, 2009

Dec 16, 2005

11/305816

Brad W. Simeral - San Francisco CA, US
David G. Reed - Saratoga CA, US
Dmitry Vyshetsky - Cupertino CA, US
Robert William Chapman - Mountain View CA, US
Joshua Titus - Sunnyvale CA, US
Anand Srinivasan - San Jose CA, US
Hari U. Krishnan - Newark CA, US

Nvidia Corporation - Santa Clara CA

G06F 1/32

713300, 713310, 713320, 713321, 713322, 713323, 713324, 713330, 713340

A data path controller, a computer device, an apparatus and a method are disclosed for integrating power management functions into a data path controller to manage power consumed by processors and peripheral devices. By embedding power management within the data path controller, the data path controller can advantageously modify its criteria in-situ so that it can adapt its power management actions in response to changes in processors and peripheral devices. In addition, the data path controller includes a power-managing interface that provides power-monitoring ports for monitoring and/or quantifying power consumption of various components. In one embodiment, the data path controller includes a power-monitoring interface for selectably monitoring power of a component. It also includes a controller for adjusting operational characteristics of the component for modifying the power consumed by the component to comply with a performance profile, which generally specifies permissible power consumption levels for the component.

7494714, Feb 24, 2009

Jul 9, 2007

11/825998

Robert G. Chapman - San Mateo CA, US
Emanuele Ostuni - Flourtown PA, US
Michael N. Liang - London, GB
Lin Yan - Princeton NJ, US
George M. Whitesides - Newton MA, US

President & Fellows of Harvard College - Cambridge MA

B32B 9/04

4284111

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

7917671, Mar 29, 2011

Dec 18, 2007

11/959450

Muralidharan Soundararajan Chilukoor - Bangalore, IN
Robert Chapman - Mountain View CA, US
Mark Alan Overby - Bothell WA, US
Suyash Ranjan - Allahabad, IN

NVIDIA Corporation - Santa Clara CA

G06F 3/00
G06F 13/00

710 38, 710316

A scalable port controller architecture supporting data streams of different speeds. In an embodiment, a port controller contains high speed receptor units and low speed receptor units, and a port routing logic connecting each external device (on corresponding port) to one of the receptors according to various registers. The port routing logic may connect an external device to one of the receptors, which determines the data rate at which data on a corresponding virtual connection from the external device is being received/sent. If the receptor does not have sufficient capacity (based on the data rate) to communicate with the external device, the connection is moved to other receptors, potentially in another control unit.

8069355, Nov 29, 2011

Dec 23, 2008

12/342865

Brad W. Simeral - San Francisco CA, US
David G. Reed - Saratoga CA, US
Dmitry Vyshetsky - Cupertino CA, US
Roman Surgutchik - Sunnyvale CA, US
Robert William Chapman - Mountain View CA, US
Joshua Titus - Sunnyvale CA, US
Anand Srinivasan - San Jose CA, US
Hari U. Krishnan - Newark CA, US

NVIDIA Corporation - Santa Clara CA

G06F 1/32

713300, 713310, 713320, 713321, 713322, 713323, 713324, 713340, 713330

A data path controller, a computer device, an apparatus and a method are disclosed for integrating power management functions into a data path controller to manage power consumed by processors and peripheral devices. By embedding power management within the data path controller, the data path controller can advantageously modify its criteria in-situ so that it can adapt its power management actions in response to changes in processors and peripheral devices. In addition, the data path controller includes a power-managing interface that provides power-monitoring ports for monitoring and/or quantifying power consumption of various components. In one embodiment, the data path controller includes a power-monitoring interface for selectably monitoring power of a component. It also includes a controller for adjusting operational characteristics of the component for modifying the power consumed by the component to comply with a performance profile, which generally specifies permissible power consumption levels for the component.