Patricia Young

40565327, Nov 1, 1977

Jun 24, 1976

5/699278

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximillian VON Strandtmann - Rockaway NJ

Warner-Lambert Company - Morris Plains NJ

C07D21389

260296R

Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyridineethanol 1-oxides having the formula I or II: ##STR1## wherein R. sub. 1 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, ortho-amino or ortho-lower alkylamino; R. sub. 2 and R. sub. 3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy or lower alkanoyloxy; the pharmaceutically acceptable acid addition salts thereof and a process for the preparation thereof are described. The compounds of this invention are useful in the prevention of allergic and asthmatic reactions.

40566196, Nov 1, 1977

Sep 8, 1975

5/611282

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximilian VON Strandtmann - Rockaway Township NJ

Warner-Lambert Company - Morris Plains NJ

C07D21389
A61K 3144

424263

1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R. sub. 1 is hydrogen or lower alkyl; R. sub. 2 and R. sub. 3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R. sub. 4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R. sub. 5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

40071936, Feb 8, 1977

Sep 8, 1975

5/611036

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximilian VON Strandtmann - Rockaway Township NJ

Warner-Lambert Company - Morris Plains NJ

C07D40104

260288CE

Substituted 3-(2-pyridinyl)-4-(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R. sub. 1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R. sub. 2 is hydrogen or lower alkyl; R. sub. 3 is hydrogen or --CH. sub. 2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.

39730204, Aug 3, 1976

Sep 8, 1975

5/611120

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximilian VON Strandtmann - Rockaway Township NJ

Warner-Lambert Company - Morris Plains NJ

A61K 31495
C07D23728

424250

3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides of the formula I: ##SPC1## wherein R is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity.

40187810, Apr 19, 1977

May 27, 1976

5/690478

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximilian VON Strandtmann - Rockaway Township NJ

Warner-Lambert Company - Morris Plains NJ

C07D49800

260297B

2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##STR1## wherein R. sub. 1, R. sub. 2 and R. sub. 3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R. sub. 4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; the pharmaceutically acceptable, acid addition salts thereof; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.

40467694, Sep 6, 1977

Oct 29, 1976

5/736788

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Max VON Strandtmann - Rockaway NJ

Warner-Lambert Company - Morris Plains NJ

C07D49104

260295T

There is disclosed 4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylic acids, salts and esters of the formula: ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R. sub. 2 is hydrogen, aralkyl or lower alkyl; R. sub. 3 is hydrogen or lower alkyl and their pharmaceutically acceptable salts. These compounds are useful in the management of allergic conditions such as bronchial asthma, hay fever and so on.

40666557, Jan 3, 1978

Oct 29, 1976

5/736926

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Max VON Strandtmann - Rockaway NJ

Warner-Lambert Company - Morris Plains NJ

C07D49104

2602955T

The present invention relates to 4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-3-carboxylic acids, salts and esters having the formula: ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R. sub. 2 is hydrogen, aralkyl or lower alkyl; R. sub. 3 is hydrogen or lower alkyl and their pharmaceutically acceptable salts. These compounds are indicated in the management of allergic conditions such as bronchial asthma, hay fever and the like.

39832376, Sep 28, 1976

Sep 8, 1975

5/611281

David T. Connor - Parsippany NJ
Patricia A. Young - Madison NJ
Maximilian VON Strandtmann - Rockaway Township NJ

Warner-Lambert Company - Morris Plains NJ

A61K 3144

424263

2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##SPC1## wherein R. sub. 1, R. sub. 2 and R. sub. 3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R. sub. 4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.