Julie K Kim

6800608, Oct 5, 2004

Jun 22, 2001

09/888005

Anthony K. Cheng - Anaheim CA
Julie S. Kim - Placentia CA

Beckman Coulter, Inc. - Fullerton CA

A61K 3800

514 8, 514 2, 435 75, 436533, 530322

This invention relates to stabilized formulations comprising a glycopeptide antibiotic immobilized on carrier particles, and more particularly stabilized vancomycin bidentate conjugate formulations for assaying the concentration of vancomycin in a test sample. The invention also relates to assay formats that utilize such stabilized formulations. The invention further provides a test kit for detecting the presence of vancomycin in a test sample, wherein the test kit includes a stabilized vancomycin conjugate formulation. The invention further provides a novel rate enhancer for immunoassays for enhancing the rate of binding of an anti-analyte antibody to the analyte.

7179658, Feb 20, 2007

Sep 6, 2001

09/947990

Anthony K. Cheng - Anaheim CA, US
Julie S. Kim - Placentia CA, US
Chan S. Oh - Chino Hills CA, US

Beckman Coulter, Inc. - Fullerton CA

G01N 33/543

436518, 435 71, 435 792, 436172, 436524, 204451

The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF) detection to determine the concentration of an analyte of interest in a sample. Such a determination is made by measuring fluorescent signal(s) (i. e. , an electropherogram) produced upon LIF of species present in the reaction mixture that are capable of producing such signals. The method of this invention produces simplified electropherograms by reducing the number of signals that must be separated and subsequently measured, and therefore increases the accuracy of the detection and/or quantification of target analyte concentration in a sample.

7556932, Jul 7, 2009

Dec 14, 2006

11/611072

Anthony K. Cheng - Anaheim CA, US
Julie S. Kim - Placentia CA, US
Chan S. Oh - Chino Hills CA, US

Beckman Coulter, Inc. - Fullerton CA

G01N 33/00

435 794, 435 71, 435 792, 436172, 436518, 436524, 204451

The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF) detection to determine the concentration of an analyte of interest in a sample. Such a determination is made by measuring fluorescent signal(s) (i. e. , an electropherogram) produced upon LIF of species present in the reaction mixture that are capable of producing such signals. The method of this invention produces simplified electropherograms by reducing the number of signals that must be separated and subsequently measured, and therefore increases the accuracy of the detection and/or quantification of target analyte concentration in a sample.

57053537, Jan 6, 1998

Jun 7, 1995

8/483288

Chan S. Oh - Chino Hills CA
Julie S. Kim - Placentia CA
Anthony K. Cheng - Anaheim CA

Beckman Instruments, Inc. - Fullerton CA

G01N 3353
G01N 33537
G01N 33543

435 792

An assay for determining the presence of an analyte of interest in a test sample containing an interfering substance that interferes with the assay is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an assay medium (i) an assay system containing components for detecting the analyte of interest, (ii) a test sample containing the analyte and an interfering substance, and (iii) an additional amount of the interfering substance in a quantity sufficient to substantially mask the effect of the interfering substance in the test sample. This reaction mixture is incubated under conditions sufficient to allow complex formation. This resultant complex formation is detected and the presence of the analyte in the test sample is determined.

51107422, May 5, 1992

Oct 19, 1990

7/600453

Frank R. Shu - La Habra Heights CA
Julie S. Kim - Placentia CA

Beckman Instruments, Inc. - Fullerton CA

G01N 27327
G01N 27333

436 18

An indirect potentiometric method and diluent for the analysis of lithium are disclosed. The diluent includes effective amounts of a pH buffer, at least one lithium salt, and a non-cationic surfactant containing at least one hydrophobic group, at least one hydrophillic group and being substantially free of polyoxyethylene groups. Most preferably, the pH buffer is tris-(hydroxymethyl)aminomethane-phosphate, the lithium salt is lithium chloride, and the surfactant is 2,4,7,9-tetramethyl-5-decyn-4,7 diol. An indirect potentiometric determination of lithium in a clinical sample comprises the steps of mixing the sample with a diluent, contacting an aliquot of the diluted sample with a lithium specific ion selective electrode and at least one ion selective electrode specifically responsive to a monovalent interfering ion, and measuring both the response of the lithium specific ion selective electrode and the monovalent interfering ion specific ion selective electrode, the responses being an indication of the concentration of lithium in the sample.

56270801, May 6, 1997

Jul 29, 1994

8/283116

Anthony K. Cheng - Anaheim CA
Julie S. Kim - Placentia CA
Chan S. Oh - Chino Hills CA

Beckman Instruments, Inc. - Fullerton CA

G01N 33546

436534

Methods for modulating the rates and dose responses of immunoassays through the incorporation of one or more detergents into the immunoassay reaction are disclosed. The methods are particularly suitable for automated immunoassay formats, especially with formats that use analyte-biotin bidentate reagents. The methods may be used to facilitate the detection of any desired, preselected pharmacological agent.

52886786, Feb 22, 1994

Aug 23, 1991

7/749074

Frank R. Shu - La Habra Heights CA
Julie S. Kim - Placentia CA

Beckman Instruments, Inc. - Fullerton CA

G01N 27327

436 18

An indirect potentiometric method and diluent for the analysis of lithium are disclosed. The diluent includes effective amounts of a pH buffer and a non-cationic surfactant comprising at least one hydrophobic group, at least one hydrophillic group and being substantially free of polyoxyethylene groups. Most preferably, the pH buffer is tris-(hydroxymethyl) aminomethane-phosphate, and the surfactant is 2, 4, 7, 9-tetramethyl-5-decyn-4,7 diol. An indirect potentiometric determination of lithium in a clinical sample comprises the steps of mixing the sample with a diluent, contacting an aliquot of the diluted sample with a lithium specific ion selective electrode and at least one ion selective elctrode specifically responsive to a monovalent interfering ion, and measuring both the response of the lithium specific ion selective electrode and the monovalent interfering ion specific ion selective electrode, the responses being an indication of the concentration of lithium in the sample.