Hua Cao Phones & Addresses
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Bradenton, FL
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5300 Oriole Ave, Chicago, IL 60656 (773) 467-9952
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Harwood Heights, IL
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Sarasota, FL
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Kenmore, WA
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El Monte, CA
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Milwaukee, WI
Publications
Us Patents
Methods For Preparing Antiviral Calanolide Compounds
View pageUS Patent:
6420571, Jul 16, 2002
Filed:
Jul 31, 2001
Appl. No.:
09/918674
Inventors:
Ze-Qi Xu - Naperville IL
Hongwei Yuan - Foster City CA
Jennifer Crabb - Chicago IL
Raghu Samy - Schaumburg IL
Ailing Li - Carol Stream IL
Hua Cao - Chicago IL
Hongwei Yuan - Foster City CA
Jennifer Crabb - Chicago IL
Raghu Samy - Schaumburg IL
Ailing Li - Carol Stream IL
Hua Cao - Chicago IL
Assignee:
Sarawak MediChem Pharmaceuticals, Inc. - Woodridge IL
International Classification:
C07D49304
US Classification:
549282
Abstract:
The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy -10-propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10 -propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy -6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (-)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.
Novel Coumarin And Chromene Compounds And Methods Of Preparation And Use Thereof For Treating Or Preventing Viral Infections
View pageUS Patent:
20030176494, Sep 18, 2003
Filed:
Nov 15, 2002
Appl. No.:
10/295340
Inventors:
Ze-Qi Xu - Woodridge IL, US
Hongwei Yuan - San Mateo CA, US
Jennifer Crabb - Chicago IL, US
Raghu Samy - Aurora IL, US
Ailing Li - Aurora IL, US
Hua Cao - Chicago IL, US
Jeff Deignan - Chicago IL, US
Lihui Sun - Audubon PA, US
Hongwei Yuan - San Mateo CA, US
Jennifer Crabb - Chicago IL, US
Raghu Samy - Aurora IL, US
Ailing Li - Aurora IL, US
Hua Cao - Chicago IL, US
Jeff Deignan - Chicago IL, US
Lihui Sun - Audubon PA, US
International Classification:
A61K031/366
A61K031/655
A61K031/55
A61K031/451
A61K031/4025
A61K031/655
A61K031/55
A61K031/451
A61K031/4025
US Classification:
514/455000, 514/217030, 514/422000, 514/321000, 514/151000
Abstract:
The present invention relates to methods of preparation and use of coumarin and chromene compounds for treating or preventing viral infections.
Methods For Preparing Antiviral Calanolide Compounds
View pageUS Patent:
6369241, Apr 9, 2002
Filed:
Apr 25, 2000
Appl. No.:
09/557821
Inventors:
Ze-Qi Xu - Naperville IL
Hongwei Yuan - Foster City CA
Jennifer Crabb - Chicago IL
Raghu Samy - Schaumburg IL
Ailing Li - Carol Stream IL
Hua Cao - Chicago IL
Hongwei Yuan - Foster City CA
Jennifer Crabb - Chicago IL
Raghu Samy - Schaumburg IL
Ailing Li - Carol Stream IL
Hua Cao - Chicago IL
Assignee:
Sarawak Medichem Pharmaceuticals, Inc. - Lemont IL
International Classification:
C07D31122
US Classification:
549277, 514453
Abstract:
The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy-10-propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10-propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy-6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-bâ]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (-)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.